The Marklund Lab - Enteric Neurobiology
The Marklund lab focuses on cell diversity in the Enteric Nervous System. By determining the variety of ENS cell subtypes, the functions they normally serve and their developmental specification we aim to improve diagnostic and therapeutic principles for gut disorders. The lab addresses these basic but critical questions by transcriptome analysis coupled with viral-based activity/gene manipulations primarily using the mouse model.
Diversity, development and immunoregulation of enteric neurons
Nature Review Gastroenterology & Hepatology, 2022
In this review I summarise key advances in enteric neuroscience in 2021. Morarach et al presented a molecular definition of enteric neuron classes (ENCs) and and a new model for their embryonic specification. Elmentaite et al published a comprehensive gut cell atlas including the developing ENS and its surrounding cell types. Yan et al discovered a role for the ENS in tuning regulatory T-cells.